DescriptionExperiments have shown that co-translational phe nomena can strongly influence protein function. A mechanistic understanding of co-translational phenomena such as nascent chain tension and protein misfolding can be gained with molecu lar dynamics simulations using multi-scale models of ribosome-nascent chain complexes (RNCs). Using atomistic and coarse-grained models of RNCs, we will measure the magnitude of the mec hanical force generated by co-translational folding, determine the effects of folding domain size and stability on this force, and investigate how codon translation rates can alter the probability of folding and misfolding.
OrganizationPennsylvania State University
Sponsor Campus GridOSG-XSEDE
Principal Investigator
Edward O'Brien
Field Of ScienceMolecular and Structural Biosciences