DescriptionThe hope for magnetoencephalographic (MEG) measurements has been to produce functional brain mapping with high spatial (mm) and temporal (msec) resolution. Realizing this hope requires answers to these questions: (1) How many sources are active within the brain? (2) Where are they located. (3) What is their time course? MEG Virtual Recording (MVR) provides these while producing noninvasive measures of intracranial neuroelectric currents as if from 2,000,000+ directly implanted electrodes. It does so from single trial (unaveraged) data, has no free parameters, and provides very strong probabilistic measures to validate the existence of each identified source. We have demonstrated efficient implementation of MVR on the Open Sciences Grid. The measured computational load of 400 SU per second of MEG data makes supercomputing essential to practical implementation of MVR. We anticipate that MVR will enable identification of specific neurophysiological biomarkers of a variety of non-structural brain pathologies which have been refractory to date, e.g. concussion, post-traumatic stress disorder.
OrganizationUniversity of Pittsburgh
DepartmentNeurological Surgery
Sponsor Campus GridOSG-XSEDE
Principal Investigator
Donald Krieger
Field Of ScienceBiological Sciences