DescriptionHow large a role does history play in evolution? Do later events depend critically on specific earlier events, or do all events occur more or less independently? If a change occurs early in evolution, does it become easier or harder to revert the change as time proceeds? We intend to explore these ideas in the context of protein evolution, by simulating sequence evolution under purifying selection and then systematically permuting the order of amino-acid substitutions.
OrganizationUniversity of Pennsylvania
Sponsor Campus GridOSG Connect
Principal Investigator
Premal Shah
Field Of ScienceEvolutionary Sciences