TG-CHE140110

NameTG-CHE140110
DescriptionMonte Carlo molecular simulation together with a coarse-grained model is used to study the single-stranded to double-stranded transition in DNA both in solution and with one strand bound to a surface. Representing DNA microarrays, hybridization on a surface is studied and the effect of surface density, strand length and sequence homology on duplex stability is investigated. Results can better inform empirical surface hybridization models.
OrganizationUniversity of New England
DepartmentChemistry and Physics
Sponsor Campus GridOSG-XSEDE
Principal Investigator
John Stubbs
Field Of ScienceChemistry
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